American Journal of Essential Oil and Natural Products


Volume 4, Issue 1

Synthesis, characterization and controlled release studies of ethyl cellulose microcapsules incorporating essential oil using an emulsion solvent evaporation method

Author(s): Devanand K. Patil, Deepika S. Agrawal, Rahul R. Mahire, Dhananjay H. More

Abstract: A promising technique has been developed to encapsulate clove oil in ethyl cellulose (EC) microcapsules using an emulsion solvent evaporation method. The method consists of emulsifying the oil with variations of core (clove oil) loading (1.5, 3.0 and 4.5) ml into EC shell material crosslinked by epichlorohydrin (ECH). Spherical capsules with a smooth and porous surface were produced and it was noted that by studies of variations of oil loading affects the stability of microcapsules. This is being demonstrated by studies of SEM images and loss on drying method. Release study of synthesized microcapsules was achieved by UV and loss on drying method. Stable and appropriate oil loading formulation was estimated by SEM images and % release of core material.
We prepared three formulations with different loading of core F1 (1.5 ml), F2 (3.0 ml) and F3 (4.5 ml) of which studies revealed that F2 formulation having 3 ml of oil loading for 1 g EC shell was appropriate for microcapsules stability and controlled release application. Furthermore, the stable F2 formulation was studied with variations of ECH loading. A (3.0), B (4.5) and C (6.0) in ml for controlled release study and concluded by U.V absorbance and kinetic studies that formulation B was appropriate for slow release of core. Formulation B was further characterized by FTIR, TGA and particle size analyzer. The controlled releases were monitored by measuring spectral absorption in the UV range and loss on drying method.

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