American Journal of Essential Oil and Natural Products


Volume 4, Issue 1

Essential oil constituents, anticancer and antimicrobial activity of Ficus mucoso and Casuarina equisetifolia leaves

Author(s): Emmanuel E Essien, Jennifer M Newby, Tameka M Walker, Isiaka A Ogunwande, William N Setzer, Olusegun Ekundayo

Abstract: Essential oils were obtained by hydrodistillation of Ficus mucoso Welw. and Casuarina equisetifolia L. leaves and analyzed for their constituents by means of gas chromatography-mass spectrometry (GC-MS). The major volatile components of F. mucoso leaves were a-phellandrene (13.0%), p-cymene (11.3%), germacrene D (10.5%), b-caryophyllene (9.7%), 1,8-cineole (9.5%) and a-copaene (8.7%). High levels of a-phellandrene (40.6%), p-cymene (15.7%), 1,8-cineole (14.1%) and terpinolene (8.4%) characterized C. equisetifolia oil. Ficus mucoso oil demonstrated strong inhibitory activity against Hs578T human breast tumor cells (98.18%) relative to PC-3 human prostate carcinoma cells (47.17%); F. mucoso and C. equisetifolia essential oils also exhibited significant antimicrobial activity (39-625 μg/mL) on pathogens employed in the assays.

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