Volume 1, Issue 1

The Cytotoxic Activity of Annona muricata Leaf Oil from Badagary, Nigeria

 

Author(s): Moses S. Owolabi, Akintayo Lanre Ogundajo, Noura S. Dosoky, and William N. Setzer Department of Chemistry, Lagos State University P.M.B. 001, Ojo, Lagos, Nigeria.

Abstract: The leaf essential oil of Annona muricata, collected from Badagary, Nigeria, was obtained by hydrodistillation and analyzed by gas chromatography – mass spectrometry.  The leaf oil was dominated by (E)-caryophyllene (38.9%) and eugenol (30.2%), with lesser amounts of α-humulene (4.3%), δ-cadinene (6.0%), and caryophyllene oxide (5.0%).  A. muricata leaf oil showed notable in-vitro cytotoxic activity on MCF-7 cells (99.2% kill at 100 μg/mL), which can be attributed to the major components.

 

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