American Journal of Essential Oils and Natural Products

AUTHOR(S): Abdulatif Olufemi Giwa-Ajeniya, Ayobami Oluwatimilehin Olatayo and Isiaka Ajani Ogunwande

ABSTRACT:Sargassum natans is a specie of brown seaweed belonging to the family Sargassaceae. It can be processed into food, pharmaceutical products, cosmetics and textiles. Besides having economic value and protection for marine biota, it is beneficial in the health field. This research was aimed at investigating the phytochemical screening, volatile chemical compositions, antioxidant and antidiabetic activities of the methanolic extract of S. natans. The antioxidant activity was tested by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays. The antidiabetic potential was assessed by evaluating the inhibitory effect of the extract on the activities of α-amylase and α-glucosidase enzymes. The volatile compositions were identified using Gas chromatography-mass spectrometry (GC-MS) analysis. The phytochemical screening showed the abundance of saponin (38.77 mg/100g), alkaloid (26.55 mg/100g), cardiac glycoside (25.45 mg/100g) and phlobatannin (21.05 mg/100g) contents. In addition, at 100 µg/mL, S. natans exhibited 78%, 64% and 65% antioxidant, α-amylase and α-glucosidase inhibitory activities. The main volatile compounds identified in S. natans were di-tert-butylphenol (58.04%), palmitic acid (24.65%), and n-nonadecanol-1 (5.98%). S. natans can be assumed to contains phytochemicals with promising antidiabetic and antioxidant activities which can serve as a source of future lead drugs for combating oxidative stress related diseases.

DOI: https://doi.org/10.22271/23219114.2025.v13.i1b.278

Pages: 120-126  |  105 Views  52 Downloads