2022, Vol. 10 Issue 1, Part A
Essential oil constituents and study of Antioxdiant, Antidiabetic Activities of Ixora coccinea L. extract from South West, Nigeria
AUTHOR(S): Moses S Owolabi, Lanre Akintayo Ogundajo, Prabodh Satyal, Balogun Idowu Abdulkabeer, Davies Rayhana Olubokola and William N Setzer
ABSTRACT:Ixora coccinea L.is a woody, evergreen and flowering shrub that is traditionally used in treatment of hypertension, menstrual irregularities, sprains and other varieties of ailments. This study investigated chemical constituents, antioxidant and antidiabetic activities of the methanol extract and essential oil from Ixora coccinea. The phytochemical analysis and in-vitro study was achieved by using standard procedures. The essential oil composition was analyzed using gas chromatography-mass spectrometry (GC-MS). The methanol extract revealed the presence of alkaloids, flavonoids, cardiac glycosides, saponins, tannins and phenolics. The quantitative analysis showed higher content of saponins (0.32 mg/g), phenolic compounds (0.30 mg/g) and alkaloids (0.14mg/g). The antidiabetic activities were concentration dependent, with lowest inhibitory activity at 20µg/mL and highest antioxidant potential at 100µg/mL. However, methanol extract exhibited lower antioxidant activities compare to the standard. Also, the extracts displayed inhibitory activity that was dose dependent against the action of α-glucosidase (IC50: 59.31µg/mL) and α-amylase (IC50:61.68µg/mL). A total of 62 constituents, 95.2% of Ixora coccinea essential oil constituents were identified. The oil wasdominatedbyselina-1, 3, 7 (11)-trien-8-one (27.6%), selina-1, 3, 7 (11)-trien-8-one epoxide (12.7%), spathulenol (9.2%), (E)-β-caryophyllene (7.6%), germacrene B (4.5%) and β-selinene (4.7%) as major constitutents. The results indicated that Ixora coccinea contain phytochemicals with promising antidiabetics and antioxidant activities, which can serve as future lead drugs in combating diabetics and oxidative stress in related diseases.
Pages: 20-26 | 294 Views 136 Downloads
How to cite this article:
Moses S Owolabi, Lanre Akintayo Ogundajo, Prabodh Satyal, Balogun Idowu Abdulkabeer, Davies Rayhana Olubokola, William N Setzer. Essential oil constituents and study of Antioxdiant, Antidiabetic Activities of Ixora coccinea L. extract from South West, Nigeria. Am J Essent Oil Nat Prod 2022;10(1):20-26.