American Journal of Essential Oils and Natural Products

AUTHOR(S): Márcia Nunes da Silva Warken, Flavia Tasmin Techera Antunes, Eliane Sempé Obach, Elenir de Fátima Wiilland, Alessandra Hubner de Souza and Alexandre de Barros Falcão Ferraz

ABSTRACT:Rosmarinus officinalis commonly known as rosemary, alecrim, or romero is a worldwide plant with antioxidant and antimicrobial potential. The present study aimed to evaluate an emulsion containing the essential oil of R. officinalis (EORO) as an open wound healer in rats. The emulsion containing 20% of EORO was produced by the technique of hot emulsification. After the creation of a full-thickness wound in each of the 30 male Wistar rats used, they were divided into three groups treated once a day with the EORO emulsion, emulsion base, or an irrigated saline solution. Cutaneous wound contraction measurements, exudate scores, and histological analysis were performed on the 0, 3rd, 6th, 9th, 12th, and 15th. The saline group presented a great contraction on days 3, 6 (p<0.05), and 9 (p<0.001) when became similar to the EORO emulsion until the next days of evaluation. After that, there were no differences between the groups. The group treated with EORO emulsion reduced the exudate scores from the 9th day (p<0.01) different from saline. On the 6th day, the EORO emulsion group showed a little granulation tissue which did increase on the 9th day and became a thin epithelium on the 15th day. Also, the EORO emulsion enhanced an accented collagenesis in the 15th day seen by the histological analysis. The study reinforces the healing properties from EORO formulated as a topical emulsion.

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