2020, Vol. 8 Issue 3, Part A
Preventive effects of the sesquiterpenic compounds of essential oil from Greenwayodendron suaveolens (Engl. & Diels) Verdc. Subsp. suaveolens stem barks on free radicals and proteins inflammation
AUTHOR(S): Patrick Hervé Betote Diboue, Maximilienne Ascension Nyegue, Christelle Kom Wayoue, Esther Del Florence Moni Ndedi, Armelle Deutou Tchamgoue and Nnanga Nga
ABSTRACT:The present study was undertaken to determine the chemical composition and evaluate the in vitro antioxidant, anti-inflammatory activities of essential oil (EO) of Greenwayodendron suaveolens (Engl. & Diels) Verdc. Subsp. suaveolens. The determination of chemical composition of EO had been carried out by Gas Chromatography and Gas Chromatography coupled to Mass Spectrometry. The total antioxidant content was determined by the Folin-Ciocalteu method. The antioxidant activities of EO were evaluated using DPPH, ABTS and FRAP methods. The anti-inflammatory effects of EO were evaluated according to in vitro Bovine Serum Albumin (BSA) denaturation and Proteinase Inhibitory Action assays. The results obtained showed the presence of α-muurolene, 14-hydroxy-9-epi-(E)-caryophyllene, α-humulene, 14-hydroxy-(Z)-caryophyllene, davanone and cubeban-11-ol with respectively proportions of 15.5%, 13.8%, 7.9%, 7.3%, 7.2% and 6.8% as major compounds in G. suaveolens EO. The EO of G. suaveolens exhibited a total antioxidant of 239.89 ± 2.13 mg EGA/mg of dry weight. Meanwhile, the free radical DPPH·and ABTS+· scavenging activities (SC50) of 15.60 ± 1.65 µg/mL and 4.69 ± 0.96 µg/mL respectively. We found a high reducing activity of G. suaveolens EO at 94.75 ± 1.66 mg EGA/mg dry weight. The G. suaveolens EO has shown a high anti-inflammatory activity through bovine serum albumin denaturation and proteinase inhibitory action with the inhibitory concentration 50 (IC50) of 183.30 ± 3.15 mg/mL and 33.62 ± 0.95 mg/mL respectively. These results suggest that G. suaveolens essential oil may offer a new source of potential therapeutic agents to prevent inflammation induced by oxidative stress, starting point of several diseases.
Pages: 25-33 | 850 Views 94 Downloads
How to cite this article:
Patrick Hervé Betote Diboue, Maximilienne Ascension Nyegue, Christelle Kom Wayoue, Esther Del Florence Moni Ndedi, Armelle Deutou Tchamgoue, Nnanga Nga. Preventive effects of the sesquiterpenic compounds of essential oil from Greenwayodendron suaveolens (Engl. & Diels) Verdc. Subsp. suaveolens stem barks on free radicals and proteins inflammation. Am J Essent Oil Nat Prod 2020;8(3):25-33.
