American Journal of Essential Oils and Natural Products
2015, Vol. 2 Issue 4, Part A
Composition and bioactivity of the essential oil of Tanacetum parthenium from a wild population growing in Tajikistan
AUTHOR(S): Farukh S. Sharopov, William N. Setzer, Salomiddin J. Isupov, Michael Wink
ABSTRACT:The essential oil of Tanacetum parthenium (L.) Schultz-Bip. was extracted by hydrodistillation and analyzed by gas-liquid chromatography - mass spectrometry (GLC-MS). Eight components were identified representing 99.8% of total oil composition. The major components were camphor (69.7-94.0%), camphene (1.7-12.2%), and bornyl acetate (4.2-8.7%). According to DPPH and ABTS analyses the volatile oil had an antioxidant activity with IC50 values of 4.82 and 0.96 mg/ml, respectively. Lipid peroxidation was inhibited by 37.1% by 1.125 mg/ml oil. The cytotoxicity of the oil was tested against HeLa, CCRF-CEM and CEM/ADR5000 cancer cell lines: IC50 values were 158.6 µg/ml for HeLa, 69.5 µg/ml for CCRF-CEM, and 83.9 µg/ml for CEM/ADR5000 cell lines. The essential oil of T. parthenium inhibits soybean5-lipoxygenase (5-LOX) with an IC50 value of 21.6 mg/ml indicating a low anti-inflammatory activity.
Pages: 32-34 | 1277 Views 19 Downloads
How to cite this article:
Farukh S. Sharopov, William N. Setzer, Salomiddin J. Isupov, Michael Wink. Composition and bioactivity of the essential oil of Tanacetum parthenium from a wild population growing in Tajikistan. Am J Essent Oil Nat Prod 2015;2(4):32-34.